Placental transport in response to altered maternal nutrition
نویسندگان
چکیده
منابع مشابه
Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon.
Intrauterine growth restriction increases the risk of perinatal complications and predisposes the infant to diabetes and cardiovascular disease in later life. Mechanisms by which maternal nutrient restriction (MNR) reduces fetal growth are poorly understood. We hypothesized that MNR decreases placental amino acid (AA) transporter activity, leading to reduced transplacental transfer of AAs. Preg...
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Maternal undernutrition (MUN) during pregnancy may lead to fetal intrauterine growth restriction (IUGR), which itself predisposes to adult risk of obesity, hypertension, and diabetes. IUGR may stem from insufficient maternal nutrient supply or reduced placental nutrient transfer. In addition, a critical role for maternal stress-induced glucocorticoids (GCs) has been suggested to contribute to b...
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Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5)...
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Short title: Maternal Obesity and Placental Fatty Acid Transport 1 2 3 Maternal Obesity Markedly Increases Placental Fatty Acid Transporter Expression and 4 Fetal Blood Triglycerides at Mid-gestation in the Ewe 5 6 Mei J. Zhu*, Yan Ma, Nathan M. Long, Min Du, and Stephen P. Ford 7 8 9 Center for the Study of Fetal Programming, Department of Animal Science, University of 10 Wyoming, Laramie, WY ...
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ژورنال
عنوان ژورنال: Journal of Developmental Origins of Health and Disease
سال: 2012
ISSN: 2040-1744,2040-1752
DOI: 10.1017/s2040174412000529